报告题目：Microbioreactor Arrays for High-Throughput Screening (HTS) in Drug Discovery and Bioprocess Development
报告地点： 2008年12月11日（星期四）上午 10点
报告地点：玉泉校区教十4115房间
报告地点：玉泉校区教十4115房间
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Microbioreactor Arrays for High-Throughput Screening (HTS) in Drug Discovery and Bioprocess Development
Shang-Tian Yang, Professor
Department of Chemical and Biomolecular Engineering
The Ohio State University
140 West 19th Avenue, Columbus, OH 43210
Phone: 1-614-292-6611; Fax: 1-614-292-3769
Email: yang.15@osu.edu
Abstract
We have developed fluorescence-based live 3D cell cultures in microwell plates and microfluidic biochips for high-throughput cytotoxicity assay and drug screening using EGFP-expressing cells. Drug responses of the cells can be monitored in real time and noninvasively. The microbioreactor arrays can also be used for medium optimization and cell culture process development. This is the first cell-based high-throughput system in 3D that can more reliably mimic in vivo environment. The microbioreactor arrays will have wide applications in drug discovery, cell culture process development, and tissue engineering. This presentation will outline the principles and methods used in this 3D HTS system and provide several application examples (cytotoxicity assay, drug efficacy study, and antibody production process optimization).
Biographical Information
Dr. S. T. Yang is Professor of Chemical and Biomolecular Engineering at the Ohio State University, where he has been on the faculty since 1985. He is also the director of Ohio Bioprocessing Research Consortium and has worked with many companies in commercial technology development. Dr. Yang received his B.S. degree in Agricultural Chemistry from National Taiwan University and M.S. and Ph.D. degrees in Biochemical Engineering from Purdue University. Dr. Yang has broad research interests in bioengineering. His current research involves biocatalysis, cell culture, tissue engineering, functional genomics, and microfluidic biochips for high-throughput cell-based assays and biodiagnostics. He has more than 150 scientific publications and 12 patents in the bioengineering field. Dr. Yang is also a co-founder of two biotechnology startup companies. He is an elected fellow of American Institute of Medical and Biological Engineering and an active member of American Institute of Chemical Engineers (AIChE) and American Chemical Society (ACS).
